In what year was amphetamine first synthesized in Germany?

Amphetamine was first synthesized in Germany in 1887. As a result, the year that aligns with historical records for the synthesis of amphetamine is indeed close to the 1800s, but specifically, it was in 1887, which is not listed among the provided choices. The option reflecting the 1800s offers a hint towards the correct time frame, even if it is not the exact year. This historical context is important as it highlights the early beginnings of amphetamine’s development, which eventually led to its use in various medical and non-medical contexts throughout the 20th century and beyond.

The other years listed, such as the early 1900s, 1930s, and 1950s, are significant in the timeline of amphetamine's usage and recognition but do not correspond with the first synthesis event. Thus, while the answer selected does hint at the right era, the most precise historical context is key to understanding the pharmaceutical development of substances like amphetamine.