Long-term abuse of methamphetamine can lead to which of the following?

Long-term abuse of methamphetamine is known to lead to both physical and psychological dependence. This dependency occurs because methamphetamine significantly alters brain chemistry and function, particularly affecting the neurotransmitters that control pleasure, motivation, and reward. Users often develop a tolerance to the drug, leading them to consume larger amounts to achieve the same effects, which further entrenches their dependence.

The development of physical dependence means that the body adapts to the drug’s presence, and withdrawal symptoms can occur when usage is reduced or stopped. Psychological dependence involves an intense craving for the drug, often accompanied by compulsive drug-seeking behavior and continued use despite harmful consequences.

In contrast, the other options suggest positive changes that do not align with the well-documented consequences of long-term methamphetamine abuse. Typically, individuals may experience decreased appetite or adverse effects on social interactions due to behavioral changes and the drug's impact on mental health.